2
The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory domain but lacked the zinc finger DNA-binding domain, and therefore the truncated Ex4a(+)WT1 isoform retained the chance to interact with the transcriptional co-activators but misplaced the opportunity to bind to promoter of downstream targets. Prior research have revealed which the N-terminal domainPLO

Comments

Who Upvoted this Story