Also, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant pressured overexpression of Ex4a(+)WT1 isoform. These success indicated that endogenous Ex4a(+)WT1 had a physiological function to advertise apoptosis.DiscussionThe WT1 gene creates 4 major isoforms by different splicing of exon 5 (17AA) and exon 9 (KTS). All 4 important isoforms are overexpressed in


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