Moreover, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant forced overexpression of Ex4a(+)WT1 isoform. These final results indicated that endogenous Ex4a(+)WT1 had a physiological function to promote apoptosis.DiscussionThe WT1 gene generates four major isoforms by alternate splicing of exon five (17AA) and exon 9 (KTS). All 4 important isoforms are over


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