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1?and?2 Denosumab can be a man monoclonal RANKL antibody presently registered in england for the #links# treatments for proof brittle bones as well as metastatic bone fragments illness.3?and?4 By disruption of RANK�CRANKL connection denosumab prevents osteoclast mediated bone damage within this osteolytic bone fragments tumour. They have been confirmed to be successful inside large cellular tumour

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