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Expanded cells did not engraft for long-term in human recipients.five The failure of MSC cocultures to support the maintenance of long-term engrafting HSCs suggested that these cultures didn't adequately recapitulate the microenvironment on the BM niche. In spite of failure to help ex vivo HSC self-renewal, the usage of MSCs as a support cell population in coculture is often a rational beginning p

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