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At 240 days of age, descriptive and statistically significant increases (P?=?0.01) in synovial IHC indices were seen in Strain 13?guinea pigs relative to their Hartley counterparts, where IL-1�� was absent or was detected occasionally (6�C24%) in minimally positive cells and/or matrix in mid-joint ROIs ( Table IIIC). In Strain 13 animals, however, IL-1�� immunostaining showed frequent (50�C75%), m

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